Novel Transactivation Domain in Erythroid Kruppel-like Factor (EKLF)

Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation

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Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice.

Erythroid Kruppel-like factor (EKLF) is a transcription factor of the C2H2 zinc-finger class that is essential for definitive erythropoiesis. We generated immortal erythroid cell lines from EKLF(-/-) fetal liver progenitor cells that harbor a single copy of the entire human beta-globin locus and then reintroduced EKLF as a tamoxifen-inducible, EKLF-mutant estrogen receptor (EKLF-ER) fusion prot...

RED CELLS Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice

Erythroid Kruppel-like factor (EKLF) is a transcription factor of the C2H2 zincfinger class that is essential for definitive erythropoiesis. We generated immortal erythroid cell lines from EKLF2/2 fetal liver progenitor cells that harbor a single copy of the entire human b-globin locus and then reintroduced EKLF as a tamoxifen-inducible, EKLF–mutant estrogen receptor (EKLF-ERTM) fusion protein....

Recombinant erythroid Kruppel-like factor fused to GATA1 upregulates globin expression in erythroid cells

The erythroid Krüppel-like factor transactivation domain is a critical component for cell-specific inducibility of a beta-globin promoter.

Erythroid Krüppel-like factor (EKLF) is an erythroid cell-specific DNA-binding protein that activates transcription from the beta-globin CACCC element, a functionally important and evolutionarily conserved component of globin as well as other erythroid cell-specific promoters and enhancers. We have attempted to elucidate the molecular role of EKLF in erythrocyte-specific transcriptional activat...